Poly-L-Lactic Acid (PLLA) | 367.5 mg per Vial | Select Quantity Below
From $742.50 / kit
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The original FDA-approved PLLA collagen stimulator - gradual, natural-looking volume that builds and lasts over two years
The Sculptra Aesthetic 3-Vial Pack is the complete, ready-to-reconstitute treatment course for full-face PLLA collagen stimulation. Each vial contains 367.5mg of pharmaceutical-grade poly-L-lactic acid microparticles. Reconstituted and injected across 2-3 sessions spaced 4-6 weeks apart, the 3-vial course delivers comprehensive, progressive facial volumization that builds naturally over 3-6 months and lasts approximately 2 or more years. This is the cornerstone of the Sculptra NYC offering.
Also see: Sculptra Twin Pack | Official info: Sculptra.com
Sculptra Aesthetic is manufactured by Galderma and is the only FDA-approved poly-L-lactic acid (PLLA) injectable indicated for correction of facial fat loss (lipoatrophy) and shallow to deep nasolabial fold wrinkles in immunocompetent patients. Unlike HA fillers that add volume directly, Sculptra works by stimulating the body's own collagen production - a process called neocollagenesis - creating natural-looking volume that builds gradually and lasts far longer than conventional fillers.
The 3-Vial Pack is the complete standard treatment course. Reconstituted with sterile water 72 hours before use, the PLLA microparticles are injected across 2-3 sessions spaced 4-6 weeks apart. Results emerge gradually over 3-6 months as new collagen scaffolding is laid down, with clinical data supporting durability of 2 or more years in most patients.
| Manufacturer | Galderma S.A., Lausanne, Switzerland |
| Active Ingredient | Poly-L-Lactic Acid (PLLA) microparticles |
| Content per Vial | 367.5 mg PLLA / 5 mL (post-reconstitution) |
| Pack Contents | 3 vials - complete full-face treatment course |
| Reconstitution | Sterile water for injection, 72 hrs before use |
| Protocol | 2-3 sessions - 4-6 weeks apart |
| FDA Status | FDA-approved (PMA P030050) |
| Longevity | 2+ years (clinical data) |
| Price (1 Kit) | $742.50 |
Sterile water for injection (diluent) is sold separately. Sculptra NYC recommends using bacteriostatic water with 0.9% benzyl alcohol for dilution to preserve reconstituted product for up to 72 hours.
Each Sculptra vial must be reconstituted with 5-8 mL of sterile water for injection at least 72 hours before administration. This hydration period allows the PLLA microparticles to fully absorb the diluent, resulting in a smooth, uniform suspension for optimal injectability and tissue distribution. Reconstituted product should be stored at 2-8C and used within 72 hours.
Sculptra is injected into the deep dermis or subcutaneous layer using a threading or depot injection technique. Typically 1 vial is used per session across the target zones - cheeks, temples, jawline, and chin. Sessions are spaced 4-6 weeks apart. Immediately after injection, the CMC carrier and water content provide a transient volume effect that dissipates within days as the carrier is absorbed, leaving PLLA microparticles in the tissue.
The PLLA microparticles trigger a mild foreign-body response, causing fibroblasts to migrate to the injection site and produce new collagen. This neocollagenesis process continues over 3-6 months following the final injection session, with patients noticing gradual, progressive volume increase during this period. The natural quality of the results - emerging slowly and integrating with the patient's own tissue - is a hallmark of PLLA treatment.
Peak collagen deposition is typically reached at 6 months post-treatment. The resulting collagen scaffold maintains facial volume for 2 or more years in most patients - significantly longer than any HA filler. PLLA is fully biodegradable, and as it is slowly metabolized, the newly formed collagen remains. Repeat treatment courses can be performed as needed to maintain results.
Sculptra Aesthetic is the treatment of choice for patients who want natural-looking, long-lasting facial volume restoration without the "done" appearance that can accompany larger HA filler treatments. It is especially well-suited for patients with diffuse volume loss across multiple facial zones, where a comprehensive approach delivers better outcomes than targeted filler placement.
See Important Safety Information below.
The 3-Vial Pack is the complete standard treatment course packaged together, offering better value per vial compared to buying single vials. Most full-face Sculptra protocols require 3 vials total, used across 2-3 sessions. Ordering as a pack ensures you have everything needed to complete the full course without re-ordering between sessions, and our 5-kit Practice Pack reduces the per-kit cost further for high-volume practices.
Results are gradual and progressive, which is one of Sculptra's most appealing characteristics. Patients typically notice the first visible improvement 4-8 weeks after the first session, with results continuing to improve for up to 6 months after the final session. Peak results - full collagen deposition - are typically visible at 6 months post-treatment. Patients should be counseled to expect a gradual process rather than immediate results.
Yes. Sculptra works well as part of a comprehensive facial rejuvenation protocol. It is frequently combined with HA fillers for immediate focal correction (e.g., lips or tear troughs), neuromodulators (Botox/Dysport) for dynamic wrinkle control, and skin-quality treatments such as Profhilo or PRP. The gradual, foundational volume Sculptra provides complements the more targeted action of other injectables.
Unlike HA fillers, Sculptra is not reversible with an enzyme. The PLLA microparticles stimulate the body's own collagen and cannot be dissolved. This makes careful patient selection and precise injection technique essential. Nodules, if they occur, can sometimes be treated with steroid injection, massage, or in rare cases, surgical removal. Practitioners should be thoroughly trained in Sculptra injection protocols before use.
Unopened Sculptra vials should be stored at room temperature (15-30C / 59-86F), protected from light. Do not freeze. Once reconstituted with sterile water, the product must be stored at 2-8C and used within 72 hours. Discard any unused reconstituted product after 72 hours. Always inspect the reconstituted suspension before use - it should appear uniform and free of aggregates.
Important Safety Information