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Jeuveau PrabotulinumtoxinA
Glabellar Lines - Hi-Pure Manufacturing - Cost Effective

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PrabotulinumtoxinA | Wholesale Per Vial

From $219.00 / vial

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Jeuveau PrabotulinumtoxinA 100 U VialWholesale price per vial
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Hi-Pure technology for consistent batch-to-batch potency - a modern, cost-effective alternative with comparable clinical outcomes to Botox

Jeuveau (PrabotulinumtoxinA) is Evolus' FDA-approved botulinum toxin type A, manufactured using a proprietary Hi-Pure process that produces one of the purest and most consistent neurotoxin formulations available. Developed as a purpose-built aesthetic neurotoxin from the outset, Jeuveau is indicated for the temporary improvement of moderate to severe glabellar frown lines in adults, offering a clinically comparable profile to Botox at a more accessible wholesale price point.

  • FDA-approved for moderate to severe glabellar frown lines in adults
  • Hi-Pure manufacturing ensures consistent batch-to-batch potency and safety
  • Comparable clinical outcomes to Botox at a more cost-effective price point
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Also see: All Neurotoxins | Official info: Jeuveau.com

Purpose-Built for Aesthetics. Proven in Clinical Trials.

Jeuveau (PrabotulinumtoxinA) was developed by Evolus with a singular focus: a cosmetic-only neurotoxin formulated through state-of-the-art Hi-Pure technology for exceptional batch-to-batch consistency. Unlike Botox, which originated as a therapeutic drug before receiving cosmetic approval, Jeuveau was designed from the ground up for aesthetic use - ensuring every vial is calibrated for precision cosmetic injection.

FDA approval came in 2019 after pivotal Phase 3 clinical trials demonstrated efficacy and safety comparable to established neurotoxins. For NYC practitioners seeking a reliable, cost-efficient alternative to Botox with strong clinical backing, Jeuveau offers an excellent option with the same 20-unit dosing paradigm and familiar onset timeline.

Key Benefits

  • 01FDA-approved 2019 for glabellar frown lines - purpose-built cosmetic neurotoxin
  • 02Hi-Pure manufacturing delivers industry-leading batch-to-batch consistency
  • 03Comparable clinical profile to Botox at a more accessible wholesale price
  • 04Standard 3-7 day onset with natural-looking 3-4 month duration
  • 0520-unit dosing paradigm - familiar for practitioners trained on Botox

Product Specifications

Product NameJeuveau
Active IngredientPrabotulinumtoxinA (Botulinum Toxin Type A)
Vial Size100 units per vial
ManufacturerEvolus, Inc.
FDA Approval2019 (glabellar frown lines)
Onset of Action3-7 days; full effect at 2 weeks
Duration3-4 months per treatment
AdministrationIntramuscular injection by licensed practitioner only

Results Timeline

Day 3-7

Initial muscle relaxation begins. Glabellar frown lines start to soften visibly as the toxin takes effect.

Week 2

Full effect is established. Glabellar lines are significantly smoothed with a natural, rested appearance.

Month 3-4

Results gradually fade as nerve signal recovery returns muscle activity. Retreatment every 3-4 months maintains results.

Current Pricing

Wholesale prices listed per vial.

Jeuveau PrabotulinumtoxinA 100 U VialWholesale price per vial
$219.00
Jeuveau PrabotulinumtoxinA 100 U - 3 Vial PackWholesale price per pack
$620.00

Pricing is subject to change. For licensed practitioners only.

Step 1: Consultation and Assessment

Your Sculptra NYC practitioner assesses your glabellar muscle activity and frown line severity. A treatment plan is created to achieve natural-looking, targeted relaxation using Jeuveau's familiar 20-unit glabellar protocol.

Step 2: Precision Injection

Jeuveau is injected into the corrugator supercilii and procerus muscles via fine-gauge needles. The procedure takes approximately 15-20 minutes with minimal discomfort. The 20-unit protocol mirrors standard Botox dosing, offering a seamless transition for experienced injectors.

Step 3: Targeted Muscle Relaxation

PrabotulinumtoxinA blocks the release of acetylcholine at the neuromuscular junction. The Hi-Pure manufacturing process ensures the toxin is exceptionally pure and free of complexing proteins, promoting a clean, precise neuromuscular blockade in treated muscles.

Step 4: Maintained Results with Regular Retreatment

Results last 3-4 months, consistent with other established botulinum toxin type A products. Many Sculptra NYC patients on a Jeuveau protocol schedule treatments every quarter and find that consistent retreatment leads to progressively softer lines over time.

Who Is Jeuveau Right For?

Jeuveau is ideal for adults with moderate to severe glabellar frown lines who want a clinically effective, cost-accessible neurotoxin without compromising on quality. It is particularly well-suited for patients who want the same outcomes as Botox but prefer a more affordable treatment cycle, as well as practices offering high-volume neurotoxin services.

For patients who have been satisfied with Botox but are open to exploring cost-efficient alternatives, Jeuveau offers a compelling option with a comparable safety record, dosing system, and clinical profile - at a meaningfully lower per-vial wholesale cost.

Ideal Candidates

  • ?Adults with moderate to severe glabellar frown lines
  • ?Patients seeking cost-effective alternatives to Botox with comparable results
  • ?Those who value Hi-Pure manufacturing and batch-to-batch consistency
  • ?New neurotoxin patients starting treatment for the first time

Not Recommended For

  • -Individuals with known hypersensitivity to botulinum toxin or formulation components
  • -Patients with neuromuscular disorders such as myasthenia gravis or Lambert-Eaton syndrome
  • -Pregnant or breastfeeding women
  • -Patients with only static (at-rest) wrinkles better addressed by fillers or collagen stimulators

A consultation with a licensed Sculptra NYC specialist is required to determine candidacy. See Important Safety Information below.

Jeuveau and Botox are both botulinum toxin type A products with the same 20-unit glabellar dosing protocol and similar onset and duration profiles. The key differences are manufacturing process (Jeuveau uses Hi-Pure technology) and price point (Jeuveau is typically more cost-efficient at the wholesale level). Jeuveau was also developed exclusively as a cosmetic neurotoxin, with no therapeutic indication.

Most patients notice the first signs of muscle relaxation and line softening within 3 to 5 days. Full results are typically visible at 2 weeks after treatment. Your practitioner may schedule a 2-week follow-up to assess outcomes and make any necessary dosing adjustments.

Clinical studies supporting FDA approval showed Jeuveau to be non-inferior to Botox for glabellar line treatment. In head-to-head trials, patients treated with both products showed similar rates of responder success, onset time, and duration of effect.

Yes. Jeuveau addresses dynamic glabellar frown lines while fillers like Juvederm and Sculptra address volume loss and structural changes. Combining neurotoxin and filler treatments is one of the most common and effective approaches in a comprehensive facial rejuvenation protocol.

There is virtually no downtime. Most patients return to their daily activities immediately after treatment. Any minor redness or injection site swelling typically resolves within 15-30 minutes. Avoid strenuous activity, lying flat, and touching the treated area for the first 4 hours post-injection.

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Important Safety Information

INDICATIONS: Jeuveau (prabotulinumtoxinA-xvfs) is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines in adults.

CONTRAINDICATIONS: Jeuveau is contraindicated in patients with known hypersensitivity to botulinum toxin or any component of the formulation, and in patients with infection at the injection site(s).

WARNINGS AND PRECAUTIONS: Jeuveau should only be administered by licensed healthcare professionals. Units of Jeuveau are not interchangeable with other botulinum toxin products. Risks include distant spread of toxin effect, ptosis, and facial asymmetry with improper placement.

MOST COMMON ADVERSE EVENTS: Headache, eyelid ptosis, injection site bruising, injection site pain, dry eye, facial paresis. Most adverse events are mild and resolve without intervention.

References: 1. Jeuveau US Prescribing Information, Evolus Inc., 2019. 2. Phase 3 PROOF+ Clinical Trial. 3. FDA BLA 761085.