Bio-Remodelling HA - Not a Filler

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Ultra-Pure High & Low MW HA | IBAG Protocol | Select Treatment Below

From $280.00 / treatment session

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Profhilo - Single Session (2 - 1mL syringes)One IBAG session - 10 injection points, face or neck

$280.00

Profhilo - Full Protocol (4 - 1mL syringes)Two IBAG sessions, 4 weeks apart - recommended full course

$520.00

Profhilo Body - Single Session (3 - 1mL syringes)Profhilo Body for skin laxity - arms, abdomen, knees

$480.00

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The original injectable skin bio-remodeller - not a filler, but a treatment that fundamentally improves skin quality from within

Profhilo is manufactured by IBSA Farmaceutici Italia and represents a genuinely new category in injectable aesthetics. Unlike conventional HA fillers that replace volume, Profhilo bio-remodels the skin itself - stimulating 4 types of collagen, elastin, and adipocyte stem cells for comprehensive skin quality improvement. It contains the highest concentration of pure HA available in an injectable product: 64mg of ultra-pure HA per 2mL treatment.

64mg ultra-pure HA - the highest HA concentration of any injectable aesthetic product
Bio-remodels - stimulates collagen I, III, IV, XVII, elastin, and adipocyte stem cells
IBAG protocol - just 5 injection points per side for full-face treatment, minimizing discomfort

Delivery

Fast Tracked Priority

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Italian IBSA Manufacture

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Back to Dermal Fillers

Profhilo - A New Category in Injectable Aesthetics

Profhilo is not a dermal filler in the traditional sense. It contains no cross-linking agents - instead, it uses a patented NAHYCO Hybrid Technology to thermally bond high molecular weight (H-HA) and low molecular weight (L-HA) hyaluronic acid into a unique hybrid cooperative complex. This complex is both a slow-release H-HA scaffold and a fast-acting L-HA stimulant, acting simultaneously at different tissue depths to trigger a comprehensive bio-remodelling cascade.

The result is not volumization but a fundamental improvement in skin quality - hydration, firmness, elasticity, and smoothness - from within. Profhilo spreads evenly through the dermis from just 5 injection points per side (the IBAG protocol), making treatment quick, precise, and minimally invasive. The full course (2 sessions, 4 weeks apart) delivers results that last approximately 6 months.

Why Practitioners Choose Profhilo

0164mg ultra-pure HA - the highest HA concentration of any injectable aesthetic product on the market
02NAHYCO Hybrid Technology - no cross-linking agents, pure biocompatible HA thermally bonded
03Stimulates collagen I, III, IV, XVII, elastin, and adipocyte stem cells - comprehensive skin remodelling
04IBAG protocol - only 5 injection points per side, minimizing patient discomfort and treatment time
05Available for face, neck, décolletage, and body - one of the most versatile skin quality treatments available

Product Specifications

Manufacturer	IBSA Farmaceutici Italia, Lugano, Switzerland
Active Ingredient	H-HA (1,100-1,400 kDa) + L-HA (80-100 kDa)
HA Concentration	64mg per 2mL (32mg H-HA + 32mg L-HA)
Technology	NAHYCO Hybrid Technology (thermal bonding, no BDDE)
Volume	2 - 1mL syringes per treatment session
Protocol	IBAG - 5 points per side (10 total), 2 sessions - 4 weeks apart
Longevity	~6 months (maintenance every 6 months)
Price Range	$280.00 - $520.00

Profhilo vs. Conventional HA Fillers

Goal - Skin bio-remodelling (Profhilo) vs. volumization/correction (conventional fillers)

Cross-linking - None in Profhilo (NAHYCO thermal bonding) vs. BDDE cross-linking in conventional fillers

Injection points - 5 per side (IBAG protocol) vs. multiple points along fold/volume zones

Treatment areas - Face, neck, décolletage, body vs. specific facial zones

The IBAG Protocol - How Profhilo Is Administered

Session 1 - First IBAG Treatment

Profhilo is injected at 5 precise anatomical points on each side of the face (10 total) known as the IBAG (Injectable Bio-Remodelling Anatomical Grid) points. These points are selected to allow the product to diffuse evenly through the dermis and superficial fat compartments from a small number of injection sites, minimizing patient discomfort and treatment time to approximately 30 minutes.

Session 2 - Four Weeks Later

A second identical session is performed 4 weeks after the first. The H-HA component from Session 1 remains in the tissue and continues to provide hydration and scaffolding while the L-HA has been metabolized and replaced by newly stimulated collagen and elastin. The second session amplifies and completes the bio-remodelling cascade.

Results - 4-8 Weeks Post-Course

Peak results are typically visible 4-8 weeks after the second session, as new collagen, elastin, and adipocyte remodelling is completed. Patients notice improved skin hydration, firmness, smoothness, and elasticity. Results typically last approximately 6 months, after which a single maintenance session is recommended.

Maintenance - Every 6 Months

After the initial 2-session course, most patients require a single maintenance session every 6 months to sustain results. Unlike conventional fillers, the cumulative remodelling effect of Profhilo means that results can build over successive maintenance sessions, with some patients reporting progressively better skin quality over time.

Ideal Candidates for Profhilo

Profhilo is an ideal treatment for patients concerned with overall skin quality rather than specific volume loss. It is particularly effective for patients experiencing skin laxity, loss of hydration, or early signs of aging who want to improve the overall texture and resilience of their skin rather than adding volume in specific zones.

Best Suited For

+Patients with skin laxity, poor skin texture, or loss of firmness - face, neck, or décolletage
+Patients seeking global skin quality improvement rather than localized volumization
+Patients who prefer minimal injection points and a quick, low-downtime treatment
+Patients in their 30s60s wanting preventive or restorative skin biostimulation
+Practitioners offering a comprehensive aesthetic menu alongside volumizing fillers and neuromodulators

Contraindications

-Known hypersensitivity to hyaluronic acid
-Active skin infection, inflammation, or autoimmune skin conditions at the treatment site
-Pregnancy or breastfeeding - safety not established
-Patients on anticoagulants - increased bruising risk at injection sites

See Important Safety Information below.

No. Profhilo is classified as a skin bio-remodeller, not a filler. It does not add volume to specific zones. Instead, it improves the overall quality of the skin - hydration, firmness, elasticity, and smoothness - by stimulating collagen, elastin, and adipocyte stem cells. It can be used alongside conventional fillers for a comprehensive facial rejuvenation approach.

The standard initial course is 2 sessions, 4 weeks apart. After the initial course, a single maintenance session every 6 months is typically recommended to sustain and build on results. Some younger patients may choose a single session, though the full 2-session course delivers optimal bio-remodelling outcomes.

IBAG stands for Injectable Bio-Remodelling Anatomical Grid. It is the specific injection technique developed for Profhilo, involving 5 precise anatomical injection points per side of the face (10 total). This minimizes the number of injection sites while ensuring even diffusion of the product through the dermis. The IBAG protocol makes Profhilo treatment quick and relatively comfortable.

Yes. Profhilo is suitable for the face, neck, and décolletage. Profhilo Body (a separate formulation) is indicated for skin laxity in areas such as the arms, abdomen, inner thighs, and knees. Different IBAG protocols have been developed for each treatment area.

Results from the initial 2-session course typically last approximately 6 months. A maintenance session every 6 months is recommended to sustain the bio-remodelling benefits. Many patients find that cumulative sessions produce progressively better skin quality, as the collagen and elastin stimulation builds over time.